Publications
Dynamin A as a one-component division machinery for synthetic cells. De Franceschi N, Barth R, Meindlhumer S, Fragasso A and Dekker C. BioRxiv 2022.12.05.519112. Accepted for publication by Nature Nanotechnology.
Engineering ssRNA tile filaments for (dis)assembly and membrane binding. De Franceschi N, Hoogenberg B and Dekker C. bioRxiv 2022.10.18.512742; doi: https://doi.org/10.1101/2022.10.18.512742
A Synthetic Membrane Shaper for controlled liposome deformation. De Franceschi N, Pezeshkian W, Fragasso A, Bruininks B, Tsai S, Marrink SJ and Dekker C. ACS Nano. 2022 Nov 28;17(2):966–78.
Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage. Azad K, Guilligay D, Boscheron C, Maity S, De Franceschi N, Sulbaran G, Effantin G, Wang H, Kleman JP, Bassereau P, Schoehn G, Roos WH, Desfosses A, Weissenhorn W. Nat Struct Mol Biol. 2023 Jan;30(1):81-90.
The archaeal division protein CdvB1 assembles into polymers that are depolymerized by CdvC. Blanch-Jover A, De Franceschi N, Fenel D, Weissenhorn W, Dekker K. FEBS Lett. 2022 Apr;596(7):958-969.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules. Fragasso A*, De Franceschi N*, Stömmer P*, van der Sluis E, Dietz H, Dekker C. ACS Nano. 2021 Jun 25;15(8):12768–79.
Optimized cDICE for Efficient Reconstitution of Biological Systems in Giant Unilamellar Vesicles. Van de Cauter L, Fanalista F, van Buren L, De Franceschi N, Godino E, Bouw S, Danelon C, Dekker C, Koenderink GH, Ganzinger KA. ACS Synth Biol. 2021 Jul 16;10(7):1690-1702 .
Towards a synthetic cell cycle. Olivi L, Berger M, Creyghton RNP, De Franceschi N, Dekker C, Mulder BM, Claassens NJ, Ten Wolde PR, van der Oost J. Nature Communication. 2021 Jul 26;12(1):4531.
The ESCRT-III Isoforms CHMP2A And CHMP2B Display Different Effects On Membranes Upon Polymerization. Alqabandi M*, De Franceschi N*, Miguet N, Maity S, Bally M, Roos WH, Weissenhorn W, Bassereau P, Mangenot S. BMC Biol. 2021 Apr 8;19(1):66.
Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation. Bertin A*, De Franceschi N*, de la Mora E, Maity S, Alqabandi M, Miguet N, di Cicco A, Roos WH, Mangenot S, Weissenhorn W, Bassereau P. Nature Communications. 2020;11(1):2663.
MASTL promotes cell contractility and motility through kinase-independent signaling. Taskinen ME, Närvä E, Conway JRW, Hinojosa LS, Lilla S, Mai A, De Franceschi N, Elo LL, Grosse R, Zanivan S, Norman JC, Ivaska J. J Cell Biol. 2020;219(6):e201906204.
Dynamic and Sequential Protein Reconstitution on Negatively Curved Membranes by Giant Vesicles Fusion. De Franceschi N, Alqabandi M, Weissenhorn W, Bassereau P. (2019). Bio-protocol 9(13): e3294.
ProLIF - quantitative integrin protein-protein interactions and synergistic membrane effects on proteoliposomes. De Franceschi N*, Miihkinen M*, Hamidi H, Alanko J, Mai A, Picas L, Guzmán C, Lévy D, Mattjus P, Goult BT, Goud B, Ivaska J. J Cell Sci. 2018;132(4):jcs214270.
The ESCRT protein CHMP2B acts as a diffusion barrier on reconstituted membrane necks. De Franceschi N, Alqabandi M, Miguet N, Caillat C, Mangenot S, Weissenhorn W, Bassereau P. J Cell Sci. 2018;132(4):jcs217968.
First person. De Franceschi N. J Cell Sci. 2018 (interview).
Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice. Peuhu E, Salomaa SI, De Franceschi N, Potter CS, Sundberg JP, Pouwels J. PLoS One. 2017;12(10):e0186628.
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J. Nature Cell Biology. 2017;19(4):292-305.
SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland. Peuhu E, Kaukonen R, Lerche M, Saari M, Guzmán C, Rantakari P, De Franceschi N, Wärri A, Georgiadou M, Jacquemet G, Mattila E, Virtakoivu R, Liu Y, Attieh Y, Silva KA, Betz T, Sundberg JP, Salmi M, Deugnier MA, Eliceiri KW, Ivaska J. EMBO J. 2017;36(2):165-182.
Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, Sihto H, Ventelä S, Elo L, Jokitalo E, Westermarck J, Kellokumpu-Lehtinen PL, Joensuu H, Grenman R, Ivaska J. Nature Communications. 2016;7:12237
Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2. De Franceschi N, Arjonen A, Elkhatib N, Denessiouk K, Wrobel AG, Wilson TA, Pouwels J, Montagnac G, Owen DJ, Ivaska J. Nature Structural & Molecular Biology. 2016;23(2):172-179.
Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling. De Franceschi N, Peuhu E, Parsons M, Rissanen S, Vattulainen I, Salmi M, Ivaska J, Pouwels J. PLoS One. 2015;10(11):e0143423.
Integrin bondage: filamin takes control. De Franceschi N, Ivaska J. Nature Structural & Molecular Biology. 2015;22(5):355-357.
Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function. Virtakoivu R, Mai A, Mattila E, De Franceschi N, Imanishi SY, Corthals G, Kaukonen R, Saari M, Cheng F, Torvaldson E, Kosma VM, Mannermaa A, Muharram G, Gilles C, Eriksson J, Soini Y, Lorens JB, Ivaska J. Cancer Res. 2015;75(11):2349-2362.
Integrin traffic - the update. De Franceschi N, Hamidi H, Alanko J, Sahgal P, Ivaska J. J Cell Sci. 2015;128(5):839-852.
Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells. Muharram G, Sahgal P, Korpela T, De Franceschi N, Kaukonen R, Clark K, Tulasne D, Carpén O, Ivaska J. Developmental Cell. 2014;29(5):629-630.
Longin and GAF domains: structural evolution and adaptation to the subcellular trafficking machinery. De Franceschi N, Wild K, Schlacht A, Dacks JB, Sinning I, Filippini F. Traffic. 2014;15(1):104-121.
SHARPIN regulates uropod detachment in migrating lymphocytes. Pouwels J*, De Franceschi N*, Rantakari P, Auvinen K, Karikoski M, Mattila E, Potter C, Sundberg JP, Hogg N, Gahmberg CG, Salmi M, Ivaska J. Cell Reports. 2013;5(3):619-628.
A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin. Hämälistö S, Pouwels J, De Franceschi N, Saari M, Ivarsson Y, Zimmermann P, Brech A, Stenmark H, Ivaska J. PLoS One. 2013;8(8):e70696.
Integrin inactivators: balancing cellular functions in vitro and in vivo Bouvard D, Pouwels J, De Franceschi N, Ivaska J.. Nat Rev Mol Cell Biol. 2013;14(7):430-442.
Improved real-time PCR assay for detection and quantification of all 54 known types of human adenoviruses in clinical samples. Bil-Lula I, De Franceschi N, Pawlik K, Woźniak M. Med Sci Monit. 2012;18(6):BR221-BR228.
Bioinformatic and mutational analysis of channelrhodopsin-2 protein cation-conducting pathway. Plazzo AP*, De Franceschi N*, Da Broi F, Zonta F, Sanasi MF, Filippini F, Mongillo M. J Biol Chem. 2012;287(7):4818-4825.
Alternative splicing of the human gene SYBL1 modulates protein domain architecture of Longin VAMP7/TI-VAMP, showing both non-SNARE and synaptobrevin-like isoforms. Vacca M, Albania L, Della Ragione F, Carpi A, Rossi V, Strazzullo M, De Franceschi N, Rossetto O, Filippini F, D'Esposito M. BMC Mol Biol. 2011;12:26. Interview.